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Biophysics: Searching for Principles
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PEN 393
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Biophysics emphasizes the unifying power of abstract physical principles to motivate new and novel experiments on biological systems.
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- A physicist's guide to the phenomena of lifeInteractions between the fields of physics and biology reach back over a century, and some of the most significant developments in biology―from the discovery of DNA's structure to imaging of the human brain―have involved collaboration across this disciplinary boundary. For a new generation of physicists, the phenomena of life pose exciting challenges to physics itself, and biophysics has emerged as an important subfield of this discipline. Here, William Bialek provides the first graduate-level introduction to biophysics aimed at physics students.Bialek begins by exploring how photon counting in vision offers important lessons about the opportunities for quantitative, physics-style experiments on diverse biological phenomena. He draws from these lessons three general physical principles―the importance of noise, the need to understand the extraordinary performance of living systems without appealing to finely tuned parameters, and the critical role of the representation and flow of information in the business of life. Bialek then applies these principles to a broad range of phenomena, including the control of gene expression, perception and memory, protein folding, the mechanics of the inner ear, the dynamics of biochemical reactions, and pattern formation in developing embryos.Featuring numerous problems and exercises throughout, Biophysics emphasizes the unifying power of abstract physical principles to motivate new and novel experiments on biological systems.Covers a range of biological phenomena from the physicist's perspectiveFeatures 200 problemsDraws on statistical mechanics, quantum mechanics, and related mathematical conceptsIncludes an annotated bibliography and detailed appendixes
| Publisher | Princeton University Press |
| Publication date | October 28, 2012 |
| Edition | Annotated |
| Language | English |
| Print length | 656 pages |
| ISBN-10 | 9780691138916 |
| ISBN-13 | 978-0691138916 |
| Item Weight | 4.25 pounds (1.93 kg) |
| Dimensions | 8.5 x 2 x 10 inches (21.6 x 5.1 x 25.4 cm) |
Who Should Buy?
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Science Students
Ideal for undergraduate and graduate students specializing in biology, physics, or related disciplines seeking foundational principles.
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Research Professionals
Beneficial for researchers exploring biophysics applications in fields like molecular biology, biochemistry, and bioengineering.
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Educators & Instructors
Useful resource for teachers seeking a comprehensive guide to teach concepts of biophysics to students effectively.
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Casual Readers
Not suitable for general audiences without a strong background in science or interest in biophysics topics.
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Molecular Biology Editorial Review
**Editorial Review of "Biophysics: Searching for Principles Annotated Edition"** "Biophysics: Searching for Principles" by Dr. William Bialek provides a rigorous and in-depth exploration of theoretical biophysics. The author aims to equip readers with foundational concepts rather than merely describing biological systems, emphasizing the necessity of a strong understanding of physical sciences, particularly statistical mechanics and thermodynamics. As such, the book is directed towards individuals with a substantial background in physics and some familiarity with biology. While non-experts may still glean insights, a lack of expertise in these areas can impede comprehension. The content navigates through complex biological phenomena, beginning with human vision and including intricate discussions about molecular workings and the fundamental principles governing biological systems. Bialek's articulation of three candidate principles of theoretical biophysics shines a spotlight on significant aspects like noise in biological devices, the nature of fine-tuning, and the role of information transfer. These principles compel readers to probe deeper into their implications and relevance, offering a robust framework for future research. Moreover, the book is skillfully designed to engage the reader; it includes an impressive array of 200 problems that encourage practical application of the concepts discussed. However, it's worth noting that the ambitious depth of content comes with a significant time and effort commitment. Despite the brilliance of the content, the presentation has garnered criticism for its physical format. The hardcover edition suffers from impractical margin and layout choices, rendering it cumbersome. This drawback, alongside the unwieldy weight of the book, discourages comfortable reading. The technical presentation in digital formats has also faced scrutiny, diminishing accessibility. In summary, those who persevere through the rigors of Bialek's "Biophysics: Searching for Principles" will be rewarded with profound insights into the marriage of physics and biology. It is a must-read for serious students and professionals in the field, despite its cumbersome format. **
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ventajas
- In-depth exploration of theoretical biophysics.
- Strong focus on foundational concepts and principles.
- Engaging practical problems encouraging application of concepts.
- Valuable for advanced students and professionals.
Contras
- Requires a significant background in physics to fully appreciate.
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características y beneficios
- First graduate-level introduction to biophysics for physics students.
- Explores significant biological phenomena through a physicist's lens.
- Includes 200 unique problems and exercises for hands-on learning.
- Covers concepts from statistical mechanics and quantum mechanics.
- Offers insights into gene expression, perception, and protein folding.
- Annotated bibliography and detailed appendixes enhance learning.
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